John T. StaskoClifford G. HammerWesley S. Culberson

The Effect of Mouse Size on Dose from an X-Rad320 Irradiator

When looking to attain consistent and reproducible results, how does variable mouse sizes affect dose delivery? Researchers in the Department of Medical Physics, University of Wisconsin School of Medicine and Public Health published their findings on this topic.

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María E. GuerraGarcía, David G.Kirsch, Zachary J.Reitman

Targeting the ATM Kinase to Enhance the Efficacy of Radiotherapy and Outcomes for Cancer Patients

Targeting the DNA damage response represents a promising approach to improve the efficacy of radiation therapy. The serine/threonine kinase ATM mediates signal transduction following DNA double strand breaks and promotes cell cycle arrest, apoptosis, senescence, and metabolic reprogramming. Because radiation therapy selectively kills cancer cells by inducing DSBs and because mice and humans lacking ATM function are sensitized to radiation, inhibiting ATM has been proposed as a strategy to improve Cancer Radiation Therapy for over 25 years.

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Michael MerrickMichael J MimlitzCatherine WeederHaris AkhterAllie BrayAndrew WaltherChisom NwakamaJoe BamesbergerHonour DjamKaamil AbidAndrew Ekpenyong 

In Vitro Radiotherapy and Chemotherapy Alter Migration of Brain Cancer Cells Before Cell Death

The more we understand cancer, the closer we are to eradicating it. Stressing the need for anti-metastasis strategies alongside chemotherapy and radiation therapy, researchers @Creighton University, Omaha, NE, using a CellRad system, irradiated cancer and non-cancer cells to determine their level of migration. It is in this migration where cancer cell metastases invade healthy tissue, causing the growth of new tumors that lead to over 90% of all cancer deaths. Together, we can not only fight cancer, but we can beat it! Contact us today to see how we can help your cancer research.

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Nathalie Donis, Zheshen Jiang, Céline D’Emal, Alexia Hulin, Margaux Debuisson, Raluca Dulgheru, Mai-Linh Nguyen, Adriana Postolache, François Lallemand, Philippe Coucke, Philippe Martinive, Marielle Herzog, Dorian Pamart, Jason Terrell, Joel Pincemail, Pierre Drion, Philippe Delvenne, Alain Nchimi, Patrizio Lancellotti, Cécile Oury

Differential Biological Effects of Dietary Lipids and Irradiation on the Aorta, Aortic Valve, and the Mitral Valve

Dietary cholesterol and palmitic acid are risk factors for cardiovascular diseases (CVDs) affecting the arteries and the heart valves. The ionizing radiation that is frequently used as an anticancer treatment promotes CVD and the specific pathophysiology of these distinct disease manifestations is poorly understood. Using rabbit models and a SmART+ irradiator, researchers study the biological effects of these dietary lipids and their cardiac irradiation on the arteries and the heart valves to help understand the relationship and improve life expectancy.

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L MaigneA DelsolG FoisE DebitonF DegoulH Payno

CPOP: An Open Source C++ Cell POPulation Modeler for Radiation Biology Applications

Continuing the fight against cancer, researchers @Université.Clermont.Auvergne in France, used a CPOP method and a Precision X-Rad320 irradiator, to successfully model cell populations and combine them with Geant14 simulations. This is a big step in studying the effects of anticancer drugs and evaluating the resistance of cancer cells under specific conditions.

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Yuxuan LiuZhimin GuHui CaoPranita KaphleJunhua LyuYuannyu ZhangWenhuo HuStephen S ChungKathryn E DickersonJian Xu 

Convergence of Oncogenic Cooperation at Single-Cell and Single-Gene Levels Drives Leukemic Transformation.

Together, researchers at the University of Texas Southwestern Medical Center and Memorial Sloan Kettering Cancer Center, worked together to evaluate functional cooperation between oncogenic drivers at single-cell and single-gene levels; identifying regulators of leukemia-initiating cells. It is studies like these that bring us another step closer in the fight against cancer.

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Ivo P Torres Filho Luciana N Torres David Barraza Charnae E Williams Kim Hildreth 

Cellular and Biochemical Effects of Combined X-Ray Radiation and Storage on Whole Blood

Blood donation is used all over the world, from remedying surgical complications to treating blood diseases and cancer. Global shortages continue to climb, making these and many other conditions difficult to address. Blood donations are only viable for 35-42 days. Evaluating the impact of ionizing radiation on stored blood is relevant since blood banks are major assets in emergency conditions.

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Lupeng Ye, Jonathan J. Park, Lei Peng, Quanjun Yan, Ryan D. Chow, Matthew B. Dong, Stanley Z. Lam, Jianjian Guo, Erting Tang, Yueqi Zhang, Guangchuan Wang, Xiaoyun Dai, Yaying Du, Hyunu R. Kim, Hanbing Cao, Youssef Errami, Paul Clark, Alexey Bersenev, Ruth R. Montgomery, Sidi Chen

A Genome-Scale Gain-of-Function CRISPR Screen in CD8 T Cells Identifies Proline Metabolism as a Means to Enhance CAR-T Therapy

Chimeric antigen receptor (CAR)-T cell-based immunotherapy for cancer and immunological diseases has made great strides, but it still faces multiple hurdles. Finding the right molecular targets to engineer T cells toward a desired function has broad implications for the armamentarium of T cell-centered therapies. Published March 10, 2022

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Georgios Lappas, Nick Staut, Natasja G. Lieuwes, Rianne Biemans, Cecile J.A. Wolfs, Stefan J. van Hoof, Ludwig J. Dubois, Frank Verhaegen

Inter-observer Variability of Organ Contouring for Preclinical Studies with Cone Beam Computed Tomography Imaging

In preclinical radiation studies, there is great interest in quantifying the radiation response of healthy tissues. Manual contouring has significant impact on the treatment-planning because of variation introduced by human interpretation. This results in inconsistencies when assessing normal tissue volumes. Published 2022

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Joyce Wei, Welby Montalvo-Ortiz, Lola Yu, Amanda Krasco, Sarah Ebstein, Czrina Cortez, Israel Lowy, Andrew J Murphy, Matthew A Sleeman, Dimitris Skokos

Sequence of αPD-1 relative to local tumor irradiation determines the induction of abscopal antitumor immune responses

Although radiotherapy has been used for over a century to locally control tumor growth, alone it rarely induces an abscopal response or systemic antitumor immunity capable of inhibiting distal tumors outside of the irradiation field. Results from recent studies suggest that combining immune checkpoint blockades to radiotherapy may enhance abscopal activity. Published 2021

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