Lupeng Ye, Jonathan J. Park, Lei Peng, Quanjun Yan, Ryan D. Chow, Matthew B. Dong, Stanley Z. Lam, Jianjian Guo, Erting Tang, Yueqi Zhang, Guangchuan Wang, Xiaoyun Dai, Yaying Du, Hyunu R. Kim, Hanbing Cao, Youssef Errami, Paul Clark, Alexey Bersenev, Ruth R. Montgomery, Sidi Chen

A Genome-Scale Gain-of-Function CRISPR Screen in CD8 T Cells Identifies Proline Metabolism as a Means to Enhance CAR-T Therapy

Chimeric antigen receptor (CAR)-T cell-based immunotherapy for cancer and immunological diseases has made great strides, but it still faces multiple hurdles. Finding the right molecular targets to engineer T cells toward a desired function has broad implications for the armamentarium of T cell-centered therapies. Published March 10, 2022

Georgios Lappas, Nick Staut, Natasja G. Lieuwes, Rianne Biemans, Cecile J.A. Wolfs, Stefan J. van Hoof, Ludwig J. Dubois, Frank Verhaegen

Inter-observer Variability of Organ Contouring for Preclinical Studies with Cone Beam Computed Tomography Imaging

In preclinical radiation studies, there is great interest in quantifying the radiation response of healthy tissues. Manual contouring has significant impact on the treatment-planning because of variation introduced by human interpretation. This results in inconsistencies when assessing normal tissue volumes. Published 2022

Joyce Wei, Welby Montalvo-Ortiz, Lola Yu, Amanda Krasco, Sarah Ebstein, Czrina Cortez, Israel Lowy, Andrew J Murphy, Matthew A Sleeman, Dimitris Skokos

Sequence of αPD-1 relative to local tumor irradiation determines the induction of abscopal antitumor immune responses

Although radiotherapy has been used for over a century to locally control tumor growth, alone it rarely induces an abscopal response or systemic antitumor immunity capable of inhibiting distal tumors outside of the irradiation field. Results from recent studies suggest that combining immune checkpoint blockades to radiotherapy may enhance abscopal activity. Published 2021

Mohammad Saki, Kruttika Bhat, Fei Cheng, Ling He, Le Zhang, Angeliki Ioannidis, David Nathanson, Jonathan Tsang, Phioanh Leia Nghiemphu,Timothy F. Cloughesy, Linda M. Liau, Harley I. Kornblum and Frank Pajonk

Combined Treatment with Dopamine Receptor Antagonists and Radiation Creates a Metabolic Vulnerability in Mouse Models of Glioblastoma

Glioblastoma is the deadliest brain tumor in adults and the standard-of-care consists of surgery followed by radiation and treatment with temozolomide. Overall survival times for patients suffering from glioblastoma are unacceptably low indicating an unmet need for novel treatment options. Published 2020

Ahmad Sharanek1, Audrey Burban1, Matthew Laaper, Emilie Heckel, Jean-Sebastien Joyal,
Vahab D. Soleimani1, & Arezu Jahani-Asl

OSMR controls glioma stem cell respiration and confers resistance of glioblastoma to ionizing radiation

Glioblastoma contains a rare population of self-renewing brain tumor stem cells (BTSCs) which are endowed with properties to proliferate, spur the growth of new tumors, and at the same time, evade ionizing radiation (IR) and chemotherapy. Published: 17 August 2020

Carolyn MacKenzie, Keisuke S Iwamoto, Kenneth Smith
University of CA

Replacement of Cesium Irradiators with Alternative Technologies.

The University of California possesses a large number of Cs irradiators that are used in a wide variety of medical and research applications. A Radioactive Source Replacement Working Group of involved faculty was formed to study the topic and to make recommendations as to when alternative technologies could offer equivalency. Health Phys 2020 Feb

Joël Daouk, Justine Jubréaux, Alicia Chateau, Hervé Schohn and Sophie Pinel
CRAN, BioSiS Department, UMR Université de Lorraine-CNRS 7039, Nancy, France

Imaging Performance of a Multimodal Module to Enhance Preclinical Irradiator Capabilities

This article highlights the performance measurements of an optical device which aims at upgrading pre-clinical irradiators. Published: 28 February, 2020

Anna Halling Folkmar Andersen, Stine Sofie Frank Nielsen, Rikke Olesen, Jakob Le Fèvre Harslund, Ole Schmeltz Søgaard, Lars Østergaard2, Paul W. Denton4, Martin Tolstrup

Comparable human reconstitution following Cesium-137 versus X-ray irradiation preconditioning in immunodeficient NOG mice

Comparable human reconstitution following Cesium-137 versus X-ray irradiation preconditioning in immunodeficient NOG mice Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark, 2 Department of Clinical Medicine, Aarhus University, Aarhus, Denmark, 3 Department of Biomedicine, Aarhus University, Aarhus, Denmark, 4 Department of Biology, University of Nebraska at Omaha, Omaha, Nebraska, United States of America

Thomas Rea WittenbornID, Cecilia Fahlquist HagertID, Alexey Ferapontov, Sofie Fonager, Lisbeth Jensen, Gudrun Winther, Søren Egedal Degn

Comparison of gamma and x-ray irradiation for myeloablation and establishment of normal and autoimmune syngeneic bone marrow chimeras

Comparison of gamma and x-ray irradiation for myeloablation and establishment of normal and autoimmune syngeneic bone marrow chimeras. The Laboratory for Lymphocyte Biology, Department of Biomedicine, Aarhus University, Aarhus, Denmark

Feng Wang, Yuan Luo, Xiaoli Tian,Shijing Ma, Yingming Sun, Chengcheng You, Yan Gongc, and Conghua Xiea

Impact of Radiotherapy Concurrent with Anti-PD-1 Therapy on the Lung Tissue of Tumor-Bearing Mice

Impact of Radiotherapy Concurrent with Anti-PD-1 Therapy on the Lung Tissue of Tumor-Bearing Mice
Radiation Research 191, 271–277 (2019) 0033-7587/19 $15.00 2019 by Radiation Research Society. All rights of reproduction in any form reserved. DOI: 10.1667/RR15182.1