I. Chiver, E. B. dos Santos, S. Valle, F. Lallemand, C. A. Cornil, G. F. Ball & J. Balthazart

Effects of the depletion of neural progenitors by focal X-ray irradiation on song production and perception in canaries

The song control nucleus HVC of songbirds has emerged as a widespread model system to study adult neurogenesis and the factors that modulate the incorporation of new neurons, including seasonal state, sex differences or sex steroid hormone concentrations. However, the specific function of these new neurons born in adulthood remains poorly understood. We implemented a new procedure based on focal X-ray irradiation to deplete neural progenitors in the ventricular zone adjacent to HVC and study the functional consequences.

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I. Gertsenshteyn, B. Epel, M. Giurcanu, E. Barth, J. Lukens, K. Hall, J. F. Martinez, M. Grana, M. Maggio, R. C. Miller, S. V. Sundramoorthy, M. Krzykawska-Serda, E. Pearson, B. Aydogan, R. R. Weichselbaum, V. M. Tormyshev, M. Kotecha, and H. J. Halpern.

Absolute Oxygen-Guided Radiation Therapy Improves Tumor Control in Three Preclinical Tumor Models

Clinical attempts to find benefit from specifically targeting and boosting resistant hypoxic tumor subvolumes have been promising but inconclusive. While a first preclinical murine tumor type showed significant improved control with hypoxic tumor boosts, a more thorough investigation of efficacy from boosting hypoxic subvolumes defined by electron paramagnetic resonance oxygen imaging (EPROI) is necessary. The present study confirms improved hypoxic tumor control results in three different tumor types using a clonogenic assay and explores potential confounding experimental conditions.

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L.M. Wang R. Yadav, M. Serban, O. Arias, J. Seuntjens, N. Ybarra

Validation of an orthotopic non-small cell lung cancer mouse model, with left or right tumor growths, to use in conformal radiotherapy studies

Orthotopic non-small cell lung cancer (NSCLC) mice models are important for establishing translatability of in vitro results. However, most orthotopic lung models do not produce localized tumors treatable by conformal radiotherapy (RT). Here we report on the performance of an orthotopic mice model featuring conformal RT treatable tumors following either left or right lung tumor cell implantation.

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J. Caravaca, R. Peter, J. Yang, C. Gunther, J. Antonio Camara Serrano, C. Nostrand, V. Sterri and Y. Seo

Comparison and calibration of dose delivered by 137Cs and X-ray irradiators in mice

The Office of Radiological Security, U.S. Department of energy's National Nuclear Security Administration, is implementing a radiological risk reduction program which seeks to minimize or eliminate the use of high activity radiological sources, including 137Cs, by replacing them with non-radioisotopic technologies, such as x-ray irradiators. The main goal of this paper is to evaluate the equivalence of the dose delivered by gamma- and x-ray irradiators in mice sing experimental measurements and Monte Carlo simulations.

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J.S Eakins, B. Afrough, R.Hewson

Monte Carlo modelling of an x-ray chamber for providing inactivation exposures to viruses

The Monte Carlo radiation transport code MCNP6 has been used to model dosimetry for biological pathogen samples

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Cleaner product: Madison firm launches antimicrobial system for cannabis growers

Helping cultivators reduce microbes and bacteria found within plants, the SteriRad system is safe and effective.

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X-Ray Radiation is a Safe and Beneficial Treatment for Cannabis

X-Ray has been used for many years in the agricultural industry, ensuring products are safe for human consumption, With the legalization of cannabis becoming more prevalent, states are setting regulations for the microbial and bacteria count that is inherent in most plants, safeguarding the population against harmful ingestion. Planning for a step to "clean" the plants is often an afterthought and can cost cultivators time, reputation and profit.

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Multi-MATE: High-Throughput Automated Small Animal Radiation Platform

Dr. Lu Jiang at UCLA works to increase the number of specimens on a SmART+ system and accelerate the time spent using the system while keeping submillimetric accuracy!

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Sara Rapic, Timothy Samuel, Patricia E. Lindsay, Steve Ansell, Robert A. Weersink, Ralph S. DaCosta

Assessing the Accuracy of Bioluminescence Image-Guided Stereotactic Body Radiation Therapy of Orthotopic Pancreatic Tumors Using a Small Animal Irradiator

Stereotactic body radiation therapy (SBRT) has shown promising results in the treatment of pancreatic cancer and other solid tumors. However, wide adoption of SBRT remains limited largely due to uncertainty about the treatment’s optimal fractionation schedules to elicit maximal tumor response while limiting the dose to adjacent structures.

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Courage MahuvavaNolan Matthew EsplenYannick PoirierStephen F KryMagdalena Bazalova-Carter

Dose calculations for preclinical radiobiology experiments conducted with single-field cabinet irradiators

Improving dose accuracy in pre-clinical research can have a direct impact in improving dose calculations in clinical radiation therapy, improving treatments and outcomes.

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